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Genome-wide association study reveals four variants that influence conception rates in cows

Decreasing fertility is an area of concern to the dairy industry. A team of Japanese researchers have recently published the results of a genome-wide association study of Holstein cattle which has uncovered four variants, located at PKP2, CTTNBP2NL, SETD6, and CACNB2, that modulate conception rates. The scientists believe that PKP2 and CTTNBP2NL may influence embryo implantation, and that SETD6 and CACNB2 are involved in the release of follicle-stimulating hormone (FSH) which regulates the reproductive process.

The study has been published in the Proceedings of the National Academy of Sciences and can be accessed by clicking here.


Journal reference: Mayumi Sugimoto, Shinji Sasaki, Yusaku Gotoh, Yuuki Nakamura, Yoshito Aoyagi, Takayoshi Kawahara, and Yoshikazu Sugimoto. Genetic variants related to gap junctions and hormone secretion influence conception rates in cows.PNAS 2013 ; published ahead of print November 11, 2013

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