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Duck genome provides new insight into fighting bird flu

The duck genome consortium, which includes scientists from China Agricultural University, BGI, University of Edinburgh and other institutes, has completed the genome sequencing and analysis of the duck (Anas platyrhynchos), a principal natural host of influenza A viruses.

The new H7N9 bird flu strain has killed 36 people and caused $6.5 billion loss to China’s economy. As a natural host of influenza A viruses (including H5N1), the duck often remains asymptomatic under influenza infection. To uncover the interactive mechanisms between the host and influenza viruses, researchers sequenced the genome of a 10-week-old female Beijing duck, and conducted transcriptomic studies on two virus-infected ducks.

This work yielded the first draft sequence of a waterfowl-duck, and the data indicated that the duck, like the chicken and zebra finch, possessed a contractive immune gene repertoire in comparson to those of mammals, and it also comprises novel genes that are not present in the other three birds (chicken, zebra finch and turkey).

By comparing gene expression in the lungs of ducks infected with either highly or weakly pathogenic avian influenza H5N1 viruses, the team identified genes whose expression patterns were altered in response to avian influenza viruses. They also identify factors that may be involved in duck host immune response to avian virus infection, including the avian and mammalian -defensin gene families.

Jianwen Li, project manager from BGI, said, “This study provides very important data to better understand the interaction between the host and the avian influenza. Scientists will be able to explore more deeply the mechanisms on the spread and infection of avian influenza.”

 

Story source: Adapted from a BGI news release, 10 Jun 2013

Journal Reference: Yinhua Huang,et al. The duck genome and transcriptome provide insight into an avian influenza virus reservoir species.Nature Genetics, 2013; DOI: 10.1038/ng.2657

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