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CRACK IT 2016 Challenges - funding to replace, reduce and refine the use of animals

The CRACK IT challenge-led competition funds collaborations between industry, academics and SMEs to solve business and scientific 'Challenges' which if solved will deliver 3Rs and commercial benefits, either by improving business processes or developing a commercialisable product.

The 2016 CRACK IT Challenges competition consists of four Challenges identified jointly by the NC3Rs and Sponsors. This year the competition is funded by the NC3Rs, co-funding provided by Arthritis Research UK (“Osteo-chip”) and ESPRC (“Osteo-chip” and “Maximise”) and supported by Innovate UK (SBRI) with in-kind contribution from the Sponsors. In total there are nine Sponsors (Arthritis Research UK, GlaxoSmithKline, MRC Harwell, Roche, Bayer, Merck, Novartis, Syngenta and Dow Agrosciences).


What are the 2016 Challenges?

To develop reliable predictions which confidently classify mixtures of chemicals, including agrochemicals, for acute oral toxicity, skin and eye irritation with a focus on relevance for human safety. 
The overall aim of the EASE CRACK IT Challenge is to generate an approach that improves the implantation rates of early stage embryos when combined with extended in vitro culture and non-surgical embryo transfer techniques. 
The overall aim is to establish a 3D retinal cell model which is physiologically-competent and predictive of human physiology. 
An in vitro model to recapitulate the human osteoarthritic joint.


Launch event, 8 September 2016, London

An event is being held to launch the competition in central London on 8 September 2016, providing invaluable access to potential new partners and to the Challenge Sponsors. Networking at the event is intended to stimulate discussion between applicants and Sponsors to help put together a winning application.

This event is free to attend but registration is essential. Please register before 1 September 2016.


Find out more about CRACK IT 2016 Challenges at

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